C677T Polymorphism of the Methylenetetrahydrofolate Reductase Gene Does Not Affect Folic Acid, Vitamin B-12, and Homocysteine Serum Levels in Turkish Children with Neural Tube Defects
Yükleniyor...
Dosyalar
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
FUNPEC-EDITORA
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Association between neural tube defects (NTDs) and C677T polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene was suspected, because the MTHFR gene codes for a key enzyme in folate metabolism. Its deficiency usually leads to significant reductions in plasma concentrations of folate, vitamin B-12 and methionine, whereas homocysteine levels are increased. We examined folate, vitamin B-12 and homocysteine serum concentrations and polymorphism of the C677T MTHFR gene in Turkish children with neural tube defects. Thirty-three children with NTDs, 26 mothers and 48 healthy individuals were studied. C677T MTHFR polymorphism was determined by melting curve analyses (LightCycler (R)). The levels of folate, vitamin B-12 and homocysteine serum concentrations in NTDs were evaluated and compared, along with information concerning alleles of the MTHFR gene. C677T allele frequencies in NTD children and their mothers were similar to those found in controls. Serum folate and vitamin B-12 concentrations were significantly higher in NTD children than that of controls. Serum homocysteine concentrations were not significantly higher in NTD children and mothers. We concluded that C677T MTHFR gene polymorphism does not affect folic acid, vitamin B-12 and homocysteine metabolism in Turkish children with NTDs. C677T polymorphism of the MTHFR gene cannot be regarded as a major risk factor for NTDs in Turkish children.
Açıklama
Anahtar Kelimeler
C677T polymorphism, Folate, Homocysteine, MTHFR, Vitamin B-12
Kaynak
Genetics and Molecular Research
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
9
Sayı
2
Künye
Büyükbaş, S., Erdoğan, M. O., Yıldız, S. H., Solak, M., Eser, O., Coşar, E., Eser, B., Köken, R., (2010). C677T Polymorphism of the Methylenetetrahydrofolate Reductase Gene Does Not Affect Folic Acid, Vitamin B-12, and Homocysteine Serum Levels in Turkish Children with Neural Tube Defects. Genetics and Molecular Research, 9(2), 1197-1203. Doi:10.4238/vol9-2gmr816
