C677T Polymorphism of the Methylenetetrahydrofolate Reductase Gene Does Not Affect Folic Acid, Vitamin B-12, and Homocysteine Serum Levels in Turkish Children with Neural Tube Defects

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dc.contributor.authorErdoğan, M. O.
dc.contributor.authorYıldız, S. H.
dc.contributor.authorSolak, M.
dc.contributor.authorEser, O.
dc.contributor.authorCoşar, E.
dc.contributor.authorEser, B.
dc.contributor.authorKöken, R.
dc.contributor.authorBüyükbaş, S.
dc.date.accessioned2020-03-26T17:47:19Z
dc.date.available2020-03-26T17:47:19Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAssociation between neural tube defects (NTDs) and C677T polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene was suspected, because the MTHFR gene codes for a key enzyme in folate metabolism. Its deficiency usually leads to significant reductions in plasma concentrations of folate, vitamin B-12 and methionine, whereas homocysteine levels are increased. We examined folate, vitamin B-12 and homocysteine serum concentrations and polymorphism of the C677T MTHFR gene in Turkish children with neural tube defects. Thirty-three children with NTDs, 26 mothers and 48 healthy individuals were studied. C677T MTHFR polymorphism was determined by melting curve analyses (LightCycler (R)). The levels of folate, vitamin B-12 and homocysteine serum concentrations in NTDs were evaluated and compared, along with information concerning alleles of the MTHFR gene. C677T allele frequencies in NTD children and their mothers were similar to those found in controls. Serum folate and vitamin B-12 concentrations were significantly higher in NTD children than that of controls. Serum homocysteine concentrations were not significantly higher in NTD children and mothers. We concluded that C677T MTHFR gene polymorphism does not affect folic acid, vitamin B-12 and homocysteine metabolism in Turkish children with NTDs. C677T polymorphism of the MTHFR gene cannot be regarded as a major risk factor for NTDs in Turkish children.en_US
dc.description.sponsorshipAfyon Kocatepe University Scientific Research Projects CommissionAfyon Kocatepe University [051.TIP.40]en_US
dc.description.sponsorshipResearch supported by the Afyon Kocatepe University Scientific Research Projects Commission (#051.TIP.40).en_US
dc.identifier.citationBüyükbaş, S., Erdoğan, M. O., Yıldız, S. H., Solak, M., Eser, O., Coşar, E., Eser, B., Köken, R., (2010). C677T Polymorphism of the Methylenetetrahydrofolate Reductase Gene Does Not Affect Folic Acid, Vitamin B-12, and Homocysteine Serum Levels in Turkish Children with Neural Tube Defects. Genetics and Molecular Research, 9(2), 1197-1203. Doi:10.4238/vol9-2gmr816
dc.identifier.doi10.4238/vol9-2gmr816en_US
dc.identifier.endpage1203en_US
dc.identifier.issn1676-5680en_US
dc.identifier.issue2en_US
dc.identifier.pmid20589617en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage1197en_US
dc.identifier.urihttps://dx.doi.org/10.4238/vol9-2gmr816
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24672
dc.identifier.volume9en_US
dc.identifier.wosWOS:000280396600061en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBüyükbaş, S.
dc.language.isoenen_US
dc.publisherFUNPEC-EDITORAen_US
dc.relation.ispartofGenetics and Molecular Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectC677T polymorphismen_US
dc.subjectFolateen_US
dc.subjectHomocysteineen_US
dc.subjectMTHFRen_US
dc.subjectVitamin B-12en_US
dc.titleC677T Polymorphism of the Methylenetetrahydrofolate Reductase Gene Does Not Affect Folic Acid, Vitamin B-12, and Homocysteine Serum Levels in Turkish Children with Neural Tube Defectsen_US
dc.typeArticleen_US

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