Total methylated arginine load as a risk parameter in subjects with masked hypertension

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dc.contributor.authorHoşaf, Müşerref
dc.contributor.authorAbuşoğlu, Sedat
dc.contributor.authorAvcı, Ahmet
dc.contributor.authorDemir, Kenan
dc.contributor.authorÜnlü, Ali
dc.contributor.authorEryavuz, Duygu
dc.contributor.authorAbuşoğlu, Gülsüm
dc.date.accessioned2020-03-26T20:20:35Z
dc.date.available2020-03-26T20:20:35Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractAsymmetric dimethylarginine, symmetric dimethylarginine, and L-monomethylarginine are originated from the subsequent proteolytic catalysis of methylated arginine residues on different proteins and inhibit the endogenous nitric oxide generation. The changes in total methylarginine load (Asymmetric dimethylarginine plus symmetric dimethylarginine plus L-monomethylarginine) may contribute to hypertension. The aim of this study was to determine serum methylarginine concentrations in patients with masked hypertension and determine the association between these biomarkers and blood pressure measurements. Control group, masked hypertension and hypertension groups consisted of 40 subjects (11 males, 28 females, mean age 48.6 +/- 13.1), 28 subjects (14 males, 14 females, mean age 50.9 +/- 11.0) and 36 subjects (15 males, 21 females, mean age 54.4 +/- 12.3 years), respectively (P= 0.149). Serum total methylarginine load was significantly higher in hypertension group (0.63 +/- 0.23) compared to masked hypertension (0.49 +/- 0.16) and control groups (0.38 +/- 0.13) (P= 0.008 and P< 0.001). While there was no statistically significant difference between healthy control groups [0.147 (0.03-0.29)] and masked hypertension patients [0.144 (0.05-0.42)] for serum symmetric dimethylarginine levels (P= 0.970), it was markedly elevated in hypertension group [0.25 (0.07-0.54)] compared to masked hypertension group [0.14 (0.05-0.42)] (P= 0.001). Serum total methylarginine load was positively correlated with night-time SBP (r = 0.214, P= 0.029). Serum methylarginine levels might be a useful marker for determining the courses of clinical hypertension.en_US
dc.identifier.citationHosaf, M., Abusoglu, S., Avci, A., Demir, K., Unlu, A., Eryavuz, D., Abusoglu, G. (2020). Total Methylated Arginine Load as a Risk Parameter in Subjects with Masked Hypertension. Clinical And Experimental Hypertension, 42(2), 126-130.
dc.identifier.doi10.1080/10641963.2019.1583246en_US
dc.identifier.endpage130en_US
dc.identifier.issn1064-1963en_US
dc.identifier.issn1525-6006en_US
dc.identifier.issue2en_US
dc.identifier.pmid30795691en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage126en_US
dc.identifier.urihttps://dx.doi.org/10.1080/10641963.2019.1583246
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38623
dc.identifier.volume42en_US
dc.identifier.wosWOS:000505789700005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorHoşaf, Müşerref
dc.institutionauthorAbuşoğlu, Sedat
dc.institutionauthorAvcı, Ahmet
dc.institutionauthorDemir, Kenan
dc.institutionauthorÜnlü, Ali
dc.institutionauthorEryavuz, Duygu
dc.institutionauthorAbuşoğlu, Gülsüm
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS INCen_US
dc.relation.ispartofCLINICAL AND EXPERIMENTAL HYPERTENSIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectSymmetric dimethylarginineen_US
dc.subjectmasked hypertensionen_US
dc.subjecttotal methylarginine loaden_US
dc.subjecttandem mass spectrometryen_US
dc.subjectblood pressureen_US
dc.titleTotal methylated arginine load as a risk parameter in subjects with masked hypertensionen_US
dc.typeArticleen_US

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