Effects of Drugs Used in Endotoxic Shock on Oxidative Stress and Organ Damage Markers
Yükleniyor...
Dosyalar
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
TAYLOR & FRANCIS LTD
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The aim of this study was to determine the effects of enrofloxacin (ENR), flunixin meglumine (FM) and dexamethasone (DEX) on antioxidant status and organ damage markers in experimentally-induced endotoxemia. Rats were divided into three groups. To induce endotoxemia, lipopolysaccharide (LPS) was injected into all groups, including the positive control. The two other groups received the following drugs (simultaneously with LPS): ENR + FM + low-dose DEX and ENR + FM + high-dose DEX. After the treatments, blood samples were collected at 0, 1, 2, 4, 6, 8, 12, 24 and 48 h. Oxidative stress parameters were determined by ELISA, while serum organ damage markers were measured by autoanalyser. LSP increased (p < 0.05) malondialdehyde, 13,14-dihydro-15-keto-prostaglandin F-2 alpha and nitric oxide, while LPS reduced vitamin C. These changes were especially inhibited (p < 0.05) by ENR + FM + high-dose DEX. LPS increased organ damages markers. Cardiac and hepatic damage was not completely inhibited by any treatment, whereas renal damage was inhibited by two treatments. This study suggested that ENR + FM + high-dose DEX is most effective in the LPS-caused oxidative stress and organ damages.
Açıklama
Anahtar Kelimeler
Oxidative stress, 13,14-dihydro-15-keto-prostaglandin F2a, enrofloxacin, flunixin, dexamethasone, organ damage
Kaynak
Free Radical Research
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
44
Sayı
4
Künye
Yazar, E., Er, A., Üney, K., Bülbül, A., Avcı, G. E., Elmas, M., Traş, B., (2010). Effects of Drugs Used in Endotoxic Shock on Oxidative Stress and Organ Damage Markers. Free Radical Research, 44(4), 397-402. Doi:10.3109/10715760903513025
