Effects of Drugs Used in Endotoxic Shock on Oxidative Stress and Organ Damage Markers

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dc.contributor.authorYazar, Enver
dc.contributor.authorEr, Ayşe
dc.contributor.authorÜney, Kamil
dc.contributor.authorBülbül, Aziz
dc.contributor.authorAvcı, Gülcan Erbil
dc.contributor.authorElmas, Muammer
dc.contributor.authorTraş, Bünyamin
dc.date.accessioned2020-03-26T17:48:11Z
dc.date.available2020-03-26T17:48:11Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study was to determine the effects of enrofloxacin (ENR), flunixin meglumine (FM) and dexamethasone (DEX) on antioxidant status and organ damage markers in experimentally-induced endotoxemia. Rats were divided into three groups. To induce endotoxemia, lipopolysaccharide (LPS) was injected into all groups, including the positive control. The two other groups received the following drugs (simultaneously with LPS): ENR + FM + low-dose DEX and ENR + FM + high-dose DEX. After the treatments, blood samples were collected at 0, 1, 2, 4, 6, 8, 12, 24 and 48 h. Oxidative stress parameters were determined by ELISA, while serum organ damage markers were measured by autoanalyser. LSP increased (p < 0.05) malondialdehyde, 13,14-dihydro-15-keto-prostaglandin F-2 alpha and nitric oxide, while LPS reduced vitamin C. These changes were especially inhibited (p < 0.05) by ENR + FM + high-dose DEX. LPS increased organ damages markers. Cardiac and hepatic damage was not completely inhibited by any treatment, whereas renal damage was inhibited by two treatments. This study suggested that ENR + FM + high-dose DEX is most effective in the LPS-caused oxidative stress and organ damages.en_US
dc.description.sponsorshipScientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [TUBITAK 107O042, SUBAPK 08401001]en_US
dc.description.sponsorshipThis study was a part of a project supported by The Scientific and Technological Research Council of Turkey (TUBITAK, 107O042) and SUBAPK (08401001).en_US
dc.identifier.citationYazar, E., Er, A., Üney, K., Bülbül, A., Avcı, G. E., Elmas, M., Traş, B., (2010). Effects of Drugs Used in Endotoxic Shock on Oxidative Stress and Organ Damage Markers. Free Radical Research, 44(4), 397-402. Doi:10.3109/10715760903513025
dc.identifier.doi10.3109/10715760903513025en_US
dc.identifier.endpage402en_US
dc.identifier.issn1071-5762en_US
dc.identifier.issn1029-2470en_US
dc.identifier.issue4en_US
dc.identifier.pmid20102316en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage397en_US
dc.identifier.urihttps://dx.doi.org/10.3109/10715760903513025
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24841
dc.identifier.volume44en_US
dc.identifier.wosWOS:000275347200004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYazar, Enver
dc.institutionauthorEr, Ayşe
dc.institutionauthorÜney, Kamil
dc.institutionauthorElmas, Muammer
dc.institutionauthorTraş, Bünyamin
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofFree Radical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectOxidative stress
dc.subject13,14-dihydro-15-keto-prostaglandin F2a
dc.subjectenrofloxacin
dc.subjectflunixin
dc.subjectdexamethasone
dc.subjectorgan damage
dc.titleEffects of Drugs Used in Endotoxic Shock on Oxidative Stress and Organ Damage Markersen_US
dc.typeArticleen_US

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