Effectiveness of MeroGel Hyaluronic Acid on Tympanic Membrane Perforations
Yükleniyor...
Dosyalar
Tarih
2006
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Conclusions. Our results support the proposition that hyaluronic acid ( HA) provides a moist wound- healing environment to aid in the healing process of tympanic membrane perforation. A single MeroGel administration can be effective as well as daily topical HA application in the treatment of tympanic membrane perforations. A single application of esterified HA may be more suitable for patients and also for otolaryngologists. Objective. The purpose of the present study was to evaluate the effectiveness of a single MeroGel application on traumatic tympanic membrane perforations in rats. Materials and methods. The posterior quadrant of the tympanic membranes in both ears of 24 male pathogen- free Sprague- Dawley rats was perforated with a 20- gauge needle. Subjects were divided into two groups: MeroGel and daily topical HA- treated groups. All subjects were sacrificed and histopathological examinations of the tympanic bullas were carried out. Results. Perforations of controls, and MeroGel- and daily HA- treated groups closed in 17/ 24 ( 70.8%), 11/ 12 ( 91.7%), and 12/ 12 ( 100%) ears, respectively. There was a significant difference between control and MeroGel- treated groups, and also between control and daily topical HA- treated groups for the presence of vascular endothelial growth factor ( VEGF), fibroblast growth factor ( FGF), lymphocytes and collagen fibrils ( p < 0.05), whereas there was no significant difference between MeroGel- and daily topical HA- treated groups ( p < 0.05).
Açıklama
Anahtar Kelimeler
application, esterified hyaluronic acid, healing, perforation, tympanic membrane
Kaynak
Acta Oto-Laryngologica
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
126
Sayı
Künye
Öztürk, K., Yaman, H., Avunduk, M. C., Arbağ, H., Keleş, B., Uyar, Y., (2006). Effectiveness of MeroGel Hyaluronic Acid on Tympanic Membrane Perforations. Acta Oto-Laryngologica, (126), 1158-1163. Doi: 10.1080/00016480600678797
