Effectiveness of MeroGel Hyaluronic Acid on Tympanic Membrane Perforations

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dc.contributor.authorÖztürk, Kayhan
dc.contributor.authorYaman, Hüseyin
dc.contributor.authorAvunduk, Mustafa Cihat
dc.contributor.authorArbağ, Hamdi
dc.contributor.authorKeleş, Bahar
dc.contributor.authorUyar, Yavuz
dc.date.accessioned2020-03-26T17:03:26Z
dc.date.available2020-03-26T17:03:26Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractConclusions. Our results support the proposition that hyaluronic acid ( HA) provides a moist wound- healing environment to aid in the healing process of tympanic membrane perforation. A single MeroGel administration can be effective as well as daily topical HA application in the treatment of tympanic membrane perforations. A single application of esterified HA may be more suitable for patients and also for otolaryngologists. Objective. The purpose of the present study was to evaluate the effectiveness of a single MeroGel application on traumatic tympanic membrane perforations in rats. Materials and methods. The posterior quadrant of the tympanic membranes in both ears of 24 male pathogen- free Sprague- Dawley rats was perforated with a 20- gauge needle. Subjects were divided into two groups: MeroGel and daily topical HA- treated groups. All subjects were sacrificed and histopathological examinations of the tympanic bullas were carried out. Results. Perforations of controls, and MeroGel- and daily HA- treated groups closed in 17/ 24 ( 70.8%), 11/ 12 ( 91.7%), and 12/ 12 ( 100%) ears, respectively. There was a significant difference between control and MeroGel- treated groups, and also between control and daily topical HA- treated groups for the presence of vascular endothelial growth factor ( VEGF), fibroblast growth factor ( FGF), lymphocytes and collagen fibrils ( p < 0.05), whereas there was no significant difference between MeroGel- and daily topical HA- treated groups ( p < 0.05).en_US
dc.identifier.citationÖztürk, K., Yaman, H., Avunduk, M. C., Arbağ, H., Keleş, B., Uyar, Y., (2006). Effectiveness of MeroGel Hyaluronic Acid on Tympanic Membrane Perforations. Acta Oto-Laryngologica, (126), 1158-1163. Doi: 10.1080/00016480600678797
dc.identifier.doi10.1080/00016480600678797en_US
dc.identifier.endpage1163en_US
dc.identifier.issn0001-6489en_US
dc.identifier.issn1651-2251en_US
dc.identifier.pmid17050307en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1158en_US
dc.identifier.urihttps://dx.doi.org/10.1080/00016480600678797
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20457
dc.identifier.volume126en_US
dc.identifier.wosWOS:000241216100006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖztürk, Kayhan
dc.institutionauthorYaman, Hüseyin
dc.institutionauthorAvunduk, Mustafa Cihat
dc.institutionauthorArbağ, Hamdi
dc.institutionauthorKeleş, Bahar
dc.institutionauthorUyar, Yavuz
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofActa Oto-Laryngologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectapplicationen_US
dc.subjectesterified hyaluronic aciden_US
dc.subjecthealingen_US
dc.subjectperforationen_US
dc.subjecttympanic membraneen_US
dc.titleEffectiveness of MeroGel Hyaluronic Acid on Tympanic Membrane Perforationsen_US
dc.typeArticleen_US

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