Prorenin and secreted frizzled-related protein 4 levels in women with gestational diabetes mellitus
Yükleniyor...
Dosyalar
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
COMENIUS UNIV
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
OBJECTIVE: This study was designed to investigate prorenin and secreted frizzled-related protein 4 (SFRP4) levels in pregnancies with or without gestational diabetes mellitus (GDM). METHODS: A total of 76 pregnant women were included in the study. Thirty-five of the pregnant women were included in GDM group according to the results of oral glucose tolerance tests (OGTT) and 41 of them were included in the control group. RESULTS: In the group with GDM, SFRP4 value was found to be significantly higher than that of the control group (5.59 +/- 3.32 ng/mL vs 4.05 +/- 2.15 ng/mL; p = 0.017). Women with GDM had significantly higher serum prorenin levels compared with control group [737 (427-1339) pg/mL vs. 535 (376-725) pg/mL; p = 0.009]. There was a significant positive association between prorenin and SFRP4 levels in GDM (r = 0.91; p < 0.001) and control groups (r = 0.42; p = 0.002) and whole pregnancies (r = 0.75; p = 0.002). CONCLUSION: We have shown that prorenin and SFRP4 were significantly elevated in GDM patients when compared to healthy control group. Furthermore, we found that there was a positive correlation between prorenin and SFRP4 (Tab. 1, Fig. 2, Ref. 38). Text in PDF www.elis.sk.
Açıklama
Anahtar Kelimeler
gestational diabetes mellitus, prorenin, SFRP 4, subclinical inflammation
Kaynak
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
119
Sayı
7
Künye
Baldane, S., Ipekci, S. H., Kebapcilar, A. G., Abusoglu, H., Beyhekim, H., Ilhan, T. T., Unlu, A., Kebapcilar, L. (2018). Prorenin and Secreted Frizzled-Related Protein 4 Levels in Women with Gestational Diabetes Mellitus. Bratislava Medical Journal-Bratıslavske Lekarske Listy, 119(7), 450-453.
