Prorenin and secreted frizzled-related protein 4 levels in women with gestational diabetes mellitus

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dc.contributor.authorBaldane, Süleyman
dc.contributor.authorİpekci, Süleyman Hilmi
dc.contributor.authorKebapcılar, Ayşe Gül
dc.contributor.authorAbuşoğlu, Sedat
dc.contributor.authorBeyhekim, Hasan
dc.contributor.authorİlhan, Tolgay Tuyan
dc.contributor.authorÜnlü, Ali
dc.contributor.authorKebapcılar, Levent
dc.date.accessioned2020-03-26T19:55:22Z
dc.date.available2020-03-26T19:55:22Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü.en_US
dc.description.abstractOBJECTIVE: This study was designed to investigate prorenin and secreted frizzled-related protein 4 (SFRP4) levels in pregnancies with or without gestational diabetes mellitus (GDM). METHODS: A total of 76 pregnant women were included in the study. Thirty-five of the pregnant women were included in GDM group according to the results of oral glucose tolerance tests (OGTT) and 41 of them were included in the control group. RESULTS: In the group with GDM, SFRP4 value was found to be significantly higher than that of the control group (5.59 +/- 3.32 ng/mL vs 4.05 +/- 2.15 ng/mL; p = 0.017). Women with GDM had significantly higher serum prorenin levels compared with control group [737 (427-1339) pg/mL vs. 535 (376-725) pg/mL; p = 0.009]. There was a significant positive association between prorenin and SFRP4 levels in GDM (r = 0.91; p < 0.001) and control groups (r = 0.42; p = 0.002) and whole pregnancies (r = 0.75; p = 0.002). CONCLUSION: We have shown that prorenin and SFRP4 were significantly elevated in GDM patients when compared to healthy control group. Furthermore, we found that there was a positive correlation between prorenin and SFRP4 (Tab. 1, Fig. 2, Ref. 38). Text in PDF www.elis.sk.en_US
dc.description.sponsorshipSelcuk UniversitySelcuk University [BAP 15401082]en_US
dc.description.sponsorshipThis study has been partially supported by Selcuk University under grant number BAP 15401082.en_US
dc.identifier.citationBaldane, S., Ipekci, S. H., Kebapcilar, A. G., Abusoglu, H., Beyhekim, H., Ilhan, T. T., Unlu, A., Kebapcilar, L. (2018). Prorenin and Secreted Frizzled-Related Protein 4 Levels in Women with Gestational Diabetes Mellitus. Bratislava Medical Journal-Bratıslavske Lekarske Listy, 119(7), 450-453.
dc.identifier.doi10.4149/BLL_2018_083en_US
dc.identifier.endpage453en_US
dc.identifier.issn0006-9248en_US
dc.identifier.issn1336-0345en_US
dc.identifier.issue7en_US
dc.identifier.pmid30160136en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage450en_US
dc.identifier.urihttps://dx.doi.org/10.4149/BLL_2018_083
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36898
dc.identifier.volume119en_US
dc.identifier.wosWOS:000440978000010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBaldane, Süleyman
dc.institutionauthorİpekci, Süleyman Hilmi
dc.institutionauthorKebapcılar, Ayşe Gül
dc.institutionauthorAbuşoğlu, Sedat
dc.institutionauthorBeyhekim, Hasan
dc.institutionauthorİlhan, Tolgay Tuyan
dc.institutionauthorÜnlü, Ali
dc.institutionauthorKebapcılar, Levent
dc.language.isoenen_US
dc.publisherCOMENIUS UNIVen_US
dc.relation.ispartofBRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectgestational diabetes mellitusen_US
dc.subjectproreninen_US
dc.subjectSFRP 4en_US
dc.subjectsubclinical inflammationen_US
dc.titleProrenin and secreted frizzled-related protein 4 levels in women with gestational diabetes mellitusen_US
dc.typeArticleen_US

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