Nerium Oleander Distillate Improves Fat and Glucose Metabolism in High-fat Diet-fed Streptozotocin-induced Diabetic Rats
Yükleniyor...
Dosyalar
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Hindawi Publishing Corporation
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Diabetes was induced by intraperitoneal injection of streptozotocin (35mg/kg bw) in all rats of five groups after being fed for 2 weeks high-fat diet. Type 2 diabetic Nerium-oleander-(NO-) administered groups received the NO distillate at a dose of 3.75, 37.5, and 375 mu g/0.5mL of distilled water (NO-0.1, NO-1, NO-10, resp.); positive control group had 0.6mg glibenclamide/kg bw/d by gavage daily for 12 weeks. Type 2 diabetic negative control group had no treatment. NO distillate administration reduced fasting blood glucose, HbA1c, insulin resistance, total cholesterol, low density lipoprotein, atherogenic index, triglyceride-HDL ratio, insulin, and leptin levels. Improved beta cell function and HDL concentration were observed by NO usage. HDL percentage in total cholesterol of all NO groups was similar to healthy control. NO-10 distillate enhanced mRNA expressions of peroxisome proliferator-activated-receptor-(PPAR-) alpha, beta, and gamma in adipose tissue and PPAR-alpha-gamma in liver. The findings from both in vivo and in vitro studies suggest that the considerable beneficial effect of NO distillate administration at a dose of 375 mu g/0.5mL of distilled water may offer new approaches to treatment strategies that target both fat and glucose metabolism in type 2 diabetes.
Açıklama
Anahtar Kelimeler
Kaynak
International Journal of Endocrinology
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
Sayı
Künye
Baş, A. L., Demirci, Ş., Yazıhan, N., Üney, K., Kaya, E. E., (2012). Nerium Oleander Distillate Improves Fat and Glucose Metabolism in High-fat Diet-fed Streptozotocin-induced Diabetic Rats. International Journal of Endocrinology, 1-10. Doi:10.1155/2012/947187
