Nerium Oleander Distillate Improves Fat and Glucose Metabolism in High-fat Diet-fed Streptozotocin-induced Diabetic Rats

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dc.contributor.authorBaş, Ahmet Levent
dc.contributor.authorDemirci, Şule
dc.contributor.authorYazıhan, Nuray
dc.contributor.authorÜney, Kamil
dc.contributor.authorKaya, Ezgi Ermiş
dc.date.accessioned2020-03-26T18:30:55Z
dc.date.available2020-03-26T18:30:55Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractDiabetes was induced by intraperitoneal injection of streptozotocin (35mg/kg bw) in all rats of five groups after being fed for 2 weeks high-fat diet. Type 2 diabetic Nerium-oleander-(NO-) administered groups received the NO distillate at a dose of 3.75, 37.5, and 375 mu g/0.5mL of distilled water (NO-0.1, NO-1, NO-10, resp.); positive control group had 0.6mg glibenclamide/kg bw/d by gavage daily for 12 weeks. Type 2 diabetic negative control group had no treatment. NO distillate administration reduced fasting blood glucose, HbA1c, insulin resistance, total cholesterol, low density lipoprotein, atherogenic index, triglyceride-HDL ratio, insulin, and leptin levels. Improved beta cell function and HDL concentration were observed by NO usage. HDL percentage in total cholesterol of all NO groups was similar to healthy control. NO-10 distillate enhanced mRNA expressions of peroxisome proliferator-activated-receptor-(PPAR-) alpha, beta, and gamma in adipose tissue and PPAR-alpha-gamma in liver. The findings from both in vivo and in vitro studies suggest that the considerable beneficial effect of NO distillate administration at a dose of 375 mu g/0.5mL of distilled water may offer new approaches to treatment strategies that target both fat and glucose metabolism in type 2 diabetes.en_US
dc.description.sponsorshipScientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [107 O 222]en_US
dc.description.sponsorshipThis work was supported by the Scientific and Technological Research Council of Turkey (Project no. 107 O 222). Also the research results were applied to Turkish Patent Institute (Application no. 2009/00312) and Patent Cooperation Treaty (Application no. PCT/TR2009/000013). All authors fully disclose that there is no financial or ethical conflict of interest.en_US
dc.identifier.citationBaş, A. L., Demirci, Ş., Yazıhan, N., Üney, K., Kaya, E. E., (2012). Nerium Oleander Distillate Improves Fat and Glucose Metabolism in High-fat Diet-fed Streptozotocin-induced Diabetic Rats. International Journal of Endocrinology, 1-10. Doi:10.1155/2012/947187
dc.identifier.doi10.1155/2012/947187en_US
dc.identifier.endpage10
dc.identifier.issn1687-8337en_US
dc.identifier.pmid23251156en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1
dc.identifier.urihttps://dx.doi.org/10.1155/2012/947187
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28254
dc.identifier.wosWOS:000312321600001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBaş, Ahmet Levent
dc.institutionauthorÜney, Kamil
dc.language.isoenen_US
dc.publisherHindawi Publishing Corporationen_US
dc.relation.ispartofInternational Journal of Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleNerium Oleander Distillate Improves Fat and Glucose Metabolism in High-fat Diet-fed Streptozotocin-induced Diabetic Ratsen_US
dc.typeArticleen_US

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