Effects of Acetylsalicylic Acid on Serum Paraoxonase Activity, Ox-LDL, Coenzyme Q10 and Other Oxidative Stress Markers in Healthy Volunteers
Yükleniyor...
Dosyalar
Tarih
2010
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
PERGAMON-ELSEVIER SCIENCE LTD
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objectives: The aim of the study was to examine the effects of acetylsalicylic acid (ASA) on oxidative stress in healthy volunteers. Design and Methods: 30 volunteers of which 17 received ASA as 100 mg/day (Group 1) and 13 received ASA as 150 mg/day (Group 11) for 2 months. Serum paraoxonase 1 (PON1), arylesterase, total antioxidant status (TAS), total oxidant status (TOS), oxidized LDL (Ox-LDL) and coenzyme Q(10) (CoQ(10)) levels were measured before and I and 2 months after treatment. Results: There was no significant differences between the measured parameters of the groups. However, TOS and Ox-LDL levels of group 11 were significantly reduced after 2 months of treatment (p<0.05). Conclusions: Significantly inhibition of LDL oxidation and significantly reduction in TOS levels of group II after 2 months of ASA treatment shows that ASA treatment may contribute to the prevention of atherosclerosis, a beneficial effect which is dose and time dependent.
Açıklama
Anahtar Kelimeler
Acetylsalicylic acid, Paraoxonase, Arylesterase, Oxidized LDL, Coenzyme Q(10), Oxidative stress
Kaynak
Clinical Biochemistry
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
43
Sayı
3
Künye
Kurban, S., Mehmetoğlu, İ., (2010). Effects of Acetylsalicylic Acid on Serum Paraoxonase Activity, Ox-LDL, Coenzyme Q10 and Other Oxidative Stress Markers in Healthy Volunteers. Clinical Biochemistry, 43(3), 287-290. Doi:10.1016/j.clinbiochem.2009.10.054
