Effects of Acetylsalicylic Acid on Serum Paraoxonase Activity, Ox-LDL, Coenzyme Q10 and Other Oxidative Stress Markers in Healthy Volunteers

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dc.contributor.authorKurban, Sevil
dc.contributor.authorMehmetoğlu, İdris
dc.date.accessioned2020-03-26T17:48:05Z
dc.date.available2020-03-26T17:48:05Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjectives: The aim of the study was to examine the effects of acetylsalicylic acid (ASA) on oxidative stress in healthy volunteers. Design and Methods: 30 volunteers of which 17 received ASA as 100 mg/day (Group 1) and 13 received ASA as 150 mg/day (Group 11) for 2 months. Serum paraoxonase 1 (PON1), arylesterase, total antioxidant status (TAS), total oxidant status (TOS), oxidized LDL (Ox-LDL) and coenzyme Q(10) (CoQ(10)) levels were measured before and I and 2 months after treatment. Results: There was no significant differences between the measured parameters of the groups. However, TOS and Ox-LDL levels of group 11 were significantly reduced after 2 months of treatment (p<0.05). Conclusions: Significantly inhibition of LDL oxidation and significantly reduction in TOS levels of group II after 2 months of ASA treatment shows that ASA treatment may contribute to the prevention of atherosclerosis, a beneficial effect which is dose and time dependent.en_US
dc.description.sponsorshipUniversity of Selcuk, Scientific Research Projects Department (BAP), Konya-TurkeySelcuk Universityen_US
dc.description.sponsorshipThis research was supported by University of Selcuk, Scientific Research Projects Department (BAP), Konya-Turkey.en_US
dc.identifier.citationKurban, S., Mehmetoğlu, İ., (2010). Effects of Acetylsalicylic Acid on Serum Paraoxonase Activity, Ox-LDL, Coenzyme Q10 and Other Oxidative Stress Markers in Healthy Volunteers. Clinical Biochemistry, 43(3), 287-290. Doi:10.1016/j.clinbiochem.2009.10.054
dc.identifier.doi10.1016/j.clinbiochem.2009.10.054en_US
dc.identifier.endpage290en_US
dc.identifier.issn0009-9120en_US
dc.identifier.issue3en_US
dc.identifier.pmid19891963en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage287en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.clinbiochem.2009.10.054
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24821
dc.identifier.volume43en_US
dc.identifier.wosWOS:000274104000011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKurban, Sevil
dc.institutionauthorMehmetoğlu, İdris
dc.language.isoenen_US
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDen_US
dc.relation.ispartofClinical Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAcetylsalicylic aciden_US
dc.subjectParaoxonaseen_US
dc.subjectArylesteraseen_US
dc.subjectOxidized LDLen_US
dc.subjectCoenzyme Q(10)en_US
dc.subjectOxidative stressen_US
dc.titleEffects of Acetylsalicylic Acid on Serum Paraoxonase Activity, Ox-LDL, Coenzyme Q10 and Other Oxidative Stress Markers in Healthy Volunteersen_US
dc.typeArticleen_US

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