Interleukin-i Beta, Tumor Necrosis Factor-Alpha Levels and Neutrophil Elastase Activity in Peri-İmplant Crevicular Fluid - Correlation With Clinical Parameters and Effect of Smoking

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dc.contributor.authorAtaoğlu, Hanife
dc.contributor.authorAlptekin, Nilgün Özlem
dc.contributor.authorHaliloğlu, Seyfullah
dc.contributor.authorGürsel, Mihtikar
dc.contributor.authorAtaoğlu, Tamer
dc.contributor.authorSerpek, Behiç
dc.contributor.authorDurmuş, Ercan
dc.date.accessioned2020-03-26T16:39:14Z
dc.date.available2020-03-26T16:39:14Z
dc.date.issued2002
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study was to determine interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) levels and neutrophil elastase (NE) activity in peri-implant crevicular fluid (PICF) of smoker and nonsmoker patients, and to investigate their relationships with clinical parameters. A total of 42 endosseous root-form dental implants of 14 patients were clinically examined by modified Plaque index (PI), modified Gingival index (Gl) and probing depth (PD). Smoking habits of the patients were recorded. PICF of implants were collected by Periopaper strips and IL-1beta, TNF-alpha levels were determined by enzyme-linked immunosorbent assay (ELISA). NE was analyzed with a neutrophil specific chromogenic substrate, N-methoxysuccinyl-Ala-Ala-Pro-Val-p-nitroanilide. The cytokine and enzyme levels in PICF were expressed as total amount/activity and as concentrations. NE activity in PICF significantly correlated with GI and PD, and IL-1beta levels with GI and PICF volume (P < 0.05). The correlations were stronger when the PICF levels were expressed as total IL-1beta amount and as total NE activity. The implants with inflamed gingiva (GI > 1) had higher levels of IL-1beta and NE activity than implants with noninflamed or slightly inflamed gingiva (GI less than or equal to 1) (P < 0.05). Total NE activity in implants with deep pockets (PD > 3 mm) was greater than the implants with shallow pockets (PD :5 3 mm) (P < 0.05). The implants of smoker patients had significantly lower PICF NE activity and IL-1beta levels, and significantly higher TNF-alpha levels than the implants of nonsmokers (P < 0.05). The findings of the present study indicate that NE activity and IL-1beta levels in PICF may be used to measure implant health status of patients who do not smoke.en_US
dc.identifier.citationAtaoğlu, H., Alptekin, N. Ö., Haliloğlu, S., Gürsel, M., Ataoğlu, T., Serpek, B., Durmuş, E., (2002). Interleukin-i Beta, Tumor Necrosis Factor-Alpha Levels and Neutrophil Elastase Activity in Peri-İmplant Crevicular Fluid - Correlation With Clinical Parameters and Effect of Smoking. Clinical Oral Implants Research, 13(5), 470-476. Doi: 10.1034/j.1600-0501.2002.130505.x
dc.identifier.doi10.1034/j.1600-0501.2002.130505.xen_US
dc.identifier.endpage476en_US
dc.identifier.issn0905-7161en_US
dc.identifier.issn1600-0501en_US
dc.identifier.issue5en_US
dc.identifier.pmid12453123en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage470en_US
dc.identifier.urihttps://dx.doi.org/10.1034/j.1600-0501.2002.130505.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17980
dc.identifier.volume13en_US
dc.identifier.wosWOS:000179799500004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAtaoğlu, Hanife
dc.institutionauthorAlptekin, Nilgün Özlem
dc.institutionauthorHaliloğlu, Seyfullah
dc.institutionauthorGürsel, Mihtikar
dc.institutionauthorAtaoğlu, Tamer
dc.institutionauthorSerpek, Behiç
dc.institutionauthorDurmuş, Ercan
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofClinical Oral Implants Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcrevicular fluiden_US
dc.subjectelastaseen_US
dc.subjectinterleukin-1en_US
dc.subjectperi-implantitisen_US
dc.subjecttumor necrosis factoren_US
dc.titleInterleukin-i Beta, Tumor Necrosis Factor-Alpha Levels and Neutrophil Elastase Activity in Peri-İmplant Crevicular Fluid - Correlation With Clinical Parameters and Effect of Smokingen_US
dc.typeArticleen_US

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