Matrix Metalloproteinases 2 and 9 Activity in Bovine Synovial Fluids

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dc.contributor.authorArıcan, M.
dc.contributor.authorCoughlan, A. R.
dc.contributor.authorClegg, D.
dc.contributor.authorCarter, S. D.
dc.date.accessioned2020-03-26T16:36:17Z
dc.date.available2020-03-26T16:36:17Z
dc.date.issued2000
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractMatrix metalloproteinases (MMPs) are important enzymes found in connective tissues and thought to be involved in cartilage degradation. They are detectable in bovine synovial fluid and may play a destructive role in bovine septic arthritis. The MMP gelatinase enzymes were detected by gelatin zymography using image analysis of the gels. The active gelatinase levels were determined by a gelatin degradation enzyme-linked immunosorbent assay (ELISA). Increased concentrations of MMP-9 activity were found in the synovial fluids of cows with septic arthritis (P < 0.001) in comparison with fluids from normal joints. Using the gelatin degradation ELISA the net active gelatinases were measured, and significant increases were found in gelatinase bioactivities in synovial fluids from septic joint disease cases (P < 0.001). Increased concentrations of MMP-2 activity were found in the synovial fluids of cows with aseptic arthritis, which appeared to be playing an important role in degradation of articular cartilage in joint disease. This finding required further investigation.en_US
dc.identifier.citationArıcan, M., Carter, S. D., Clegg, D., Coughlan, A. R., (2000). Matrix Metalloproteinases 2 and 9 Activity in Bovine Synovial Fluids. Journal of Veterinary Medicine Series a-physiology Pathology Clinical Medicine, 47(8), 449-456. Doi: 10.1046/j.1439-0442.2000.00291.x
dc.identifier.doi10.1046/j.1439-0442.2000.00291.xen_US
dc.identifier.endpage456en_US
dc.identifier.issn0931-184Xen_US
dc.identifier.issue8en_US
dc.identifier.pmid11075535en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage449en_US
dc.identifier.urihttps://dx.doi.org/10.1046/j.1439-0442.2000.00291.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17229
dc.identifier.volume47en_US
dc.identifier.wosWOS:000089978000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorArıcan, M.
dc.language.isoenen_US
dc.publisherWıleyen_US
dc.relation.ispartofJournal of Veterinary Medicine Series a-physiology Pathology Clinical Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleMatrix Metalloproteinases 2 and 9 Activity in Bovine Synovial Fluidsen_US
dc.typeArticleen_US

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