Advanced imaging in adult diffusely infiltrating low-grade gliomas
Yükleniyor...
Dosyalar
Tarih
2019
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
SPRINGEROPEN
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The adult diffusely infiltrating low-grade gliomas (LGGs) are typically IDH mutant and slow-growing gliomas having moderately increased cellularity generally without mitosis, necrosis, and microvascular proliferation. Supra-total resection of LGG significantly increases the overall survival by delaying malignant transformation compared with a simple debulking so accurate MR diagnosis is crucial for treatment planning. Data from meta-analysis support the addition of diffusion and perfusion-weighted MR imaging and MR spectroscopy in the diagnosis of suspected LGG. Typically, LGG has lower cellularity (ADCmin), angiogenesis (rCBVmax), capillary permeability (Ktrans), and mitotic activity (Cho/Cr ratio) compared to high-grade glioma. The identification of 2-hydroxyglutarate by MR spectroscopy can reflect the IDH status of the tumor. The initial low ADCmin, high rCBVmax, and Ktrans values are consistent with the poor prognosis. The gradual increase in intratumoral Cho/Cr ratio and rCBVmax values are well correlated with tumor progression. Besides MR-based technical artifacts, which are minimized by the voxel-based assessment of data obtained by histogram analysis, the problems derived from the diversity and the analysis of imaging data should be solved by using artificial intelligence techniques. The quantitative multiparametric MR imaging of LGG can either improve the diagnostic accuracy of their differential diagnosis or assess their prognosis.
Açıklama
Anahtar Kelimeler
Astrocytoma (grade II), Oligodendroglioma (adult), Magnetic resonance imaging
Kaynak
INSIGHTS INTO IMAGING
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
10
Sayı
1
Künye
Bulakbaşı, N., Paksoy, Y. (2019). Advanced Imaging in Adult Diffusely Infiltrating Low-Grade Gliomas. Insights into Imaging, 10(1).
