Advanced imaging in adult diffusely infiltrating low-grade gliomas

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dc.authorid0000-0001-7528-8107
dc.contributor.authorBulakbasi, Nail.
dc.contributor.authorPaksoy, Yahya.
dc.date.accessioned2020-03-26T20:12:27Z
dc.date.available2020-03-26T20:12:27Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractThe adult diffusely infiltrating low-grade gliomas (LGGs) are typically IDH mutant and slow-growing gliomas having moderately increased cellularity generally without mitosis, necrosis, and microvascular proliferation. Supra-total resection of LGG significantly increases the overall survival by delaying malignant transformation compared with a simple debulking so accurate MR diagnosis is crucial for treatment planning. Data from meta-analysis support the addition of diffusion and perfusion-weighted MR imaging and MR spectroscopy in the diagnosis of suspected LGG. Typically, LGG has lower cellularity (ADCmin), angiogenesis (rCBVmax), capillary permeability (Ktrans), and mitotic activity (Cho/Cr ratio) compared to high-grade glioma. The identification of 2-hydroxyglutarate by MR spectroscopy can reflect the IDH status of the tumor. The initial low ADCmin, high rCBVmax, and Ktrans values are consistent with the poor prognosis. The gradual increase in intratumoral Cho/Cr ratio and rCBVmax values are well correlated with tumor progression. Besides MR-based technical artifacts, which are minimized by the voxel-based assessment of data obtained by histogram analysis, the problems derived from the diversity and the analysis of imaging data should be solved by using artificial intelligence techniques. The quantitative multiparametric MR imaging of LGG can either improve the diagnostic accuracy of their differential diagnosis or assess their prognosis.en_US
dc.identifier.citationBulakbaşı, N., Paksoy, Y. (2019). Advanced Imaging in Adult Diffusely Infiltrating Low-Grade Gliomas. Insights into Imaging, 10(1).
dc.identifier.doi10.1186/s13244-019-0793-8en_US
dc.identifier.issn1869-4101en_US
dc.identifier.issue1en_US
dc.identifier.pmid31853670en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.1186/s13244-019-0793-8
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37456
dc.identifier.volume10en_US
dc.identifier.wosWOS:000510616800003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorPaksoy, Yahya.
dc.language.isoenen_US
dc.publisherSPRINGEROPENen_US
dc.relation.ispartofINSIGHTS INTO IMAGINGen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAstrocytoma (grade II)en_US
dc.subjectOligodendroglioma (adult)en_US
dc.subjectMagnetic resonance imagingen_US
dc.titleAdvanced imaging in adult diffusely infiltrating low-grade gliomasen_US
dc.typeArticleen_US

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