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    Akut apandisitte iskemi modifiye albümin
    (2012) Bostancı, Hasan; Kurban, Sevil; Erbay, Ekrem; Köksal, Hande
    Amaç: Akut apandisitli (AA) hastalarda iskemi modifiye albumin (İMA) düzeyinin saptanması ve prognostik öneminin değerlendirilmesidir. Yöntem ve Gereçler: AA tanısı alan 61 hasta (K/E: 32/29) ile sağlıklı 30 kişi (K/E: 17/13) çalışmaya dahil edildi. Çalışma grubunda kan örnekleri ameliyat öncesi dönemde alındı. İMA düzeyleri kalorimetrik yöntemle ölçüldü ve sonuçlar absorbans ünitesi (ABSU) cinsinden rapor edildi. Bulgular: Akut apandisitli hastalar ile kontrol grubunun İMA değerleri sırası ile 0,420,17 ABSU ve 0,370,13 ABSU idi. Hasta grubunda İMA değeri kontrol grubuna göre daha yüksek olmasına karşın aradaki fark istatistiksel olarak anlamlı değildi (p0,05). Yakınma süresi uzun olan, lökositozu ya da nötrofilisi olan hastalarda serum İMA düzeyi daha yüksek olmasına karşın aradaki farklar istatistiksel olarak anlamlı değildi (p0,05). Ancak, perfore AA’li hastaların serum İMA düzeyleri diğer alt gruplardan daha yüksek bulundu (p0,001). Sonuç: AA’de inflamasyona bağlı olarak serum İMA düzeyinde yükseklik olmasına karşın, lümen içi basınç artışı, ödem, inflamasyon ve apendiks dokusunun beslenme bozukluğunun maksimum olduğu perfore AA’li hastalarda serum İMA düzeyinin daha yüksek olduğu gözlendi.
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    Atorvastatin Pretreatment Diminishes the Levels of Myocardial Ischemia Markers Early After CABG Operation: An Observational Study
    (Biomed Central Ltd, 2010) Ege, Erdal; Dereli, Yüksel; Kurban, Sevil; Sarıgül, Ali
    Background: Statin pretreatment has been associated with a decrease in myocardial ischemia markers after various procedures and cardiovascular events. This study examined the potential beneficial effects of preoperative atorvastatin treatment among patients undergoing on-pump CABG operation. Methods: Twenty patients that had received atorvastatin treatment for at least 15 days prior to the operation and 20 patients who had not received any antihyperlipidemic agent prior to surgery were included in this study. CK-MB and troponin I levels were measured at baseline and 24 hours after the operation. Perioperative variables were also recorded. Results: Twenty-four hours after the operation, troponin I and CK-MB levels were significantly lower in the atorvastatin group: for CK-MB levels, 12.9 +/- 4.3 versus 18.7 +/- 7.4 ng/ml, p = 0.004; for troponin I levels, 1.7 +/- 0.3 versus 2.7 +/- 0.7 ng/ml, p < 0.001. In addition, atorvastatin use was associated with a decrease in the duration of ICU stay. Conclusions: Preoperative atorvastatin treatment results in significant reductions in the levels of myocardial injury markers early after on-pump CABG operation, suggesting a reduction in perioperative ischemia in this group of patients. Further studies are needed to elucidate the mechanisms of these potential benefits of statin pretreatment.
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    Çay, baharat ve bitki kaynaklı bazı gıda maddelerinin flavonoid içerikleri ve antioksidan özellikleri
    (2005) Mehmetoğlu, İdris; Ünlü, Muhteşem Cemile; Gökçe, Recep; Kurban, Sevil
    Serbest radikaller ve antioksidan (AO) denge insan sağlığı açısından büyük öneme sahiptir. Dışardan besinlerle çeşitli AO’lar alınmakta olup bunların başlıcaları AO vitaminler ve flavonoidler adı verilen bileşiklerdir. Son yıllarda çok sayıda önemli AO flavonoid keşfedilmiş ve kaynakları incelenmiştir. Flavonoidlerin en önemli kaynağı da başta çay olmak üzere baharatlar ve çeşitli sebze ve meyvelerdir. AO içeriği yüksek gıdalarla beslenme (sebze, meyve ve diğerleri) kanser, diabetes mellitus, yaşlanma, kardiyovasküler ve serebrovasküler hastalıkları da kapsayan bir grup hastalığa karşı korunma sağlar. Bu derlemedeki amacımız sıkça tüketilen çay, baharatlar ve bitki kaynaklı diğer bazı gıda maddelerinin flavonoid içeriklerini ve AO özelliklerini irdelemektir.
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    Comparison of Salivary Cortisol, Serum Cortisol, Plasma ACTH and Urinary Free Cortisol Levels in Thyrotoxic and Hypothyroid Patients
    (Turkiye Klinikleri, 2012) Gönen, Mustafa Sait; Özkaya, Emin; Kurban, Sevil; İpekçi, Süleyman Hilmi; Duran, Cevdet; Kulaksızoğlu, Sevsen
    Hypothalamo-pituitary-adrenal (HPA) axis is affected by thyroid hormones. The present study was designed to compare the level of salivary cortisol, serum cortisol, plasma ad-renocorticotropic hormone (ACTH) and urinary free cortisol (UFC) levels in patients with subcli- nical and overt thyrotoxicosis and hypothyroidism. Material and Methods: W e analyzed the salivary cortisol, serum cortisol, plasma ACTH and UFC levels in 123 patients with thyroid dysfunction. The patients were classified into four groups; overt thyrotoxicosis (n= 32), subclinical thyrotoxico-sis (n= 29), overt hypothyroidism (n= 28) and subclinical hypothyroidism (n= 34). Results: There we-re no significant differences in terms of salivary cortisol, serum cortisol, plasma ACTH and UFC levels in patients with subclinical and overt thyrotoxicosis (p> 0.05). Similarly, no significant dif-ferences could be detected in terms of salivary cortisol, serum cortisol, plasma ACTH and UFC le-vels in patients with subclinical and overt hypothyroidism (p> 0.05). The comparison of patients with hypothyroidism and thyrotoxicosis also did not yield any significant difference in terms of sa-livary cortisol, serum cortisol, plasma ACTH and UFC levels (p> 0.05). Conclusion: Similar salivary cortisol, serum cortisol, plasma ACTH and UFC levels were detected in patients with hypothyroi-dism and thyrotoxicosis. Thus, we may suggest that thyroid hormone status does not play a role in the HPA axis. The major limitation of this study was the absence of a healthy control group. Furt-her studies with large numbers of patients are required to clarify the association between thyroid hormone dysfunction and glucocorticoid levels.
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    Comparison of urinary neutrophil gelatinase-associated lipocalin, C-reactive protein and procalcitonin in the diagnosis of late onset sepsis in preterm newborns
    (TAYLOR & FRANCIS LTD, 2013) Ertuğrul, Sabahattin; Annagür, Ali; Kurban, Sevil; Altunhan, Hüseyin; Örs, Rahmi
    [Abstract not Available]
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    Correlation between vitamin A, E, coenzyme Q(10) and degree of insulin resistance in obese and non-obese subjects
    (JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION, 2011) Mehmetoglu, Idris; Yerlikaya, F. Humeyra; Kurban, Sevil
    The aim of the present study was to investigate correlation between plasma vitamin A, vitamin E, serum coenzyme Q(10) levels and degree of insulin resistance in obese and normal weight people. The study was performed on 98 (21 Male, 77 Female) obese people and 78 (20 Male, 58 Female) control subjects. Vitamin A, E and coenzyme Q(10) levels were adjusted to the lipid levels. Adjusted vitamin A and E and coenzyme Q(10) levels of the obese female group were significantly lower than those of the control female group. Adjusted vitamin A and coenzyme Q(10) levels of the obese male group were significantly lower than those of the control male group. Insulin resistance level of the obese female and male groups were significantly higher than that of the control female and male groups. There were no significant correlations between serum coenzyme Q(10), plasma vitamin A and E levels and insulin resistance in obese and control subjects. Our findings show that it is essential to use the lipid adjusted levels of lipid soluble nutrients in obesity. Also, we have found no association between insulin resistance and vitamin A, vitamin E and coenzyme Q10 levels in obese subjects.
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    Diagnostic and prognostic value of procalcitonin and phosphorus in acute mesenteric ischemia
    (TURKISH ASSOC TRAUMA EMERGENCY SURGERY, 2011) Karabulut, Keziban; Gul, Mehmet; Dundar, Zerrin Defne; Cander, Basar; Kurban, Sevil; Toy, Hatice
    BACKGROUND In this study, using an animal model of acute mesenteric ischemia (AMI), we investigated the possible use of procalcitonin and phosphorus in the early diagnosis of AMI. METHODS In this study, 21 New Zealand rabbits were used. Subjects were allocated into three groups as Control, Sham and Ischemia. No intervention was performed in the subjects in the Control group. In the subjects in the Sham and Ischemia groups, laparotomy was performed with midline incision. In the Ischemia group, the superior mesenteric artery was found and tied after laparotomy. Blood was drawn from the animals in all groups at 0, 1, 3 and 6 hours, and procalcitonin and phosphorus levels were studied in these samples. RESULTS In the Ischemia group, the increase in the levels of serum phosphorus and procalcitonin was found to be statistically significant compared to the Control and Sham groups (p < 0.05). The levels of phosphorus and procalcitonin were detected to increase from the 1st hour after ischemia onset, and the increase continued for the following 6 hours (p < 0.05). CONCLUSION Phosphorus and procalcitonin may be important parameters for use in the early diagnosis and prognosis of AMI.
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    Diyet yağlarının beyinde lipid peroksidasyonu, AOA, NO ve lipidler üzerine olan etkilerinin araştırılması
    (Selçuk Üniversitesi Tıp Fakültesi, 2005) Kurban, Sevil; Mehmetoğlu, İdris
    Çalışmamızda toplum tarafından en çok tüketilen yağlar olan ayçiçek yağı, zeytin yağı, margarin, soya yağı ve tereyağının beyinde kolesterol, trigiiserid (TG), fosfolipid, lipid pe-oksidasyonu, antioksidan aktivite (AOA) ve nitrik oksit (NO) düzeyleri üzerine olan etkilerini araştırmayı amaçladık. Bunun için, 72 adet dişi rat alındı ve her birinde 12 adet olmak üzere 6 gruba ayrıldı. Kontrol grubu standart laboratuar yemi ile, diğer gruplar % 15 oranında yukarıda belirtilen yağları içeren yem ile 8 hafta süre ile beslendi. Bu süre sonunda fareler dekapite edilerek beyin örnekleri alındı. Beyin dokusu homojenize edilerek kolesterol, TG, fosfolipid, malondialdehid (MDA), AOA ve NO düzeyleri ölçüldü ve aşağıdaki bulgular elde edildi: 1- Grupların beyin MDA ve NO değerleri arasında istatistik! açıdan önemli bir fark bulunamadı. 2- Gruplara ait en yüksek AOA değeri zeytinyağı grubunda en düşük değer soya yağı grubunda bulundu. Bu parametreye göre yağlar büyükten küçüğe doğru zeytin yağı > tereyağı > kontrol > margarin > ayçiçek yağı > soya yağı şeklinde sıralanmaktadır. Gruplara ait AOA değerleri karşılaştırıldığında zeytin yağı grubunun değerleri kontrol (p<0.05), margarin (p<0.001), ayçiçek yağı (p<0.00i) ve soya yağı (p<0.001) grubunun değerlerinden, tereyağı grubunun değeri ayçiçek yağı (p<0.01) ve soya yağı (p<0.001) grabunun değerlerinden ve kontrol grubunun değerleri ayçiçek yağı (p<0.05) ve soya yağı (p<0.01) grubunun değerlerinden önemli derecede yüksek bulundu. 3- Grupların beyin kolesterol değerleri büyükten küçüğe doğru zeytin yağı > ayçiçek yağı > soya yağı > margarin > tereyağı > kontrol şeklinde sıralanmaktadır. Bu gruplardan, zeytin yağı grubunun değerleri diğer gruplardan (p< 0.001), ayçiçek yağı grubunun değerleri soya yağı, margarin, tere yağı ve kontrol (soya yağı-p<0.05, diğerieri-p<0.001) grubunun değerlerinden ve soya yağı grabunun değerleri margarin (p<0.005), tereyağı (p<0.005) ve kontrol grabunun değerlerinden (p<0.001) önemli derecede yüksek bulundu. 4- Grupların beyin TG değerleri büyükten küçüğe doğru zeytin yağı > soya yağı > ayçiçek yağı > tereyağı > kontrol > margarin şeklinde sıralanmaktadır. Grupların TG değerleri karşılaştırıldığında, zeytin yağı grabunun değerleri kontrol, margarin, ayçiçek yağı ve tereyağı gruplarının değerlerinden (p<0.001), soya yağı grabunun değerleri kontrol ve margarin gruplarının değerlerinden (p<0.001) ve ayçiçek yağı grabunun değerleri margarin grubundan (p<0.05) önemli derecede yüksek bulundu. 62 5- Grupların beyin fosfolipid değerleri büyükten küçüğe doğru zeytin yağı > soya yağı > kontrol > margarin > ayçiçek yağı > tereyağı şeklinde sıralanmaktadır. Bu grupların fosfolipid değerleri karşılaştırıldığında zeytin yağı ve soya yağı gruplarının değerleri kontrol, margarin, ayçiçek yağı ve tereyağı gruplarının değerlerinden önemli derecede yüksek bulunurken ilk iki grubun fosfolipid değerleri arasındaki fark önemli değildir. Gruplarımıza ait beyin lipid düzeyindeki değişiklikleri ve bu değişikliklerin organizma açısından etkilerini izah edemedik. Dolayısı ile, bu önemli bulgunun daha ileri araştırmalarla değerlendirilmesi gerektiği kanaatindeyiz. Sonuç olarak, yağlar antioksidan özellikleri açısından değerlendirildiğinde sağlık açısından en faydalı yağın zeytinyağı olduğu ve bunu sırası ile tereyağı, margarin, ayçiçek yağı ve soya yağının takip ettiği söylenebilir.
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    The effect of alcohol on total antoxidant activity and nitric oxide levels in the sera and brains of rats
    (TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, 2008) Kurban, Sevil; Mehmetoglu, Idris
    Background: The present study investigated the effect of alcohol consumption on total antioxidant activity (AOA) and nitric oxide (NO) levels in the sera and brains of rats. Materials and methods: The study included 24 rats that were divided into 2 groups: the control group (n = 12) and the alcohol group (n = 12). Both groups were fed regular laboratory chow and tap water for a period of 2 months; however, the alcohol group received 15% (v/v) ethanol in their drinking water. Then, the rats were decapitated, and serum and brain AOA and NO levels were measured. Results: Both serum and brain AOA of the alcohol group were significantly lower than those of the control group. Serum NO levels of the alcohol group were significantly higher, whereas brain NO levels were lower, but not significantly, than those of the control group. Conclusion: Our findings show that alcohol diminished both serum and brain defense mechanisms against free radical attack, which might result in many diseases. Moreover, decreased AOA levels in the alcohol group might be a significant cause of increased serum NO levels in this group or vice versa: however, the effects of alcohol on brain NO levels require further investigation.
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    Effect of Chronic Regular Exercise on Serum Ischemia-Modified Albumin Levels and Oxidative Stress in Type 2 Diabetes Mellitus
    (TAYLOR & FRANCIS INC, 2011) Kurban, Sevil; Mehmetoglu, Idris; Yerlikaya, Humeyra F.; Gonen, Sait; Erdem, Sami
    Objectives. Our aim was to determine the effect of chronic regular exercise on ischemia-modified albumin (IMA) levels and oxidative stress in type 2 diabetes mellitus (DM). Design and methods. Sixty patients with type 2 DM were randomly divided into two groups as exercise (17 M, 13 F) and non-exercise (12 M, 18 F) groups, each consisting of 30 patients. The exercise group underwent a 3-month aerobic regular exercise consisting of moderate-intensity power walking. The non-exercise subjects remained sedentary throughout the study period. Serum total antioxidant status (TAS), total oxidant status (TOS), and IMA levels of the groups were determined at baseline and 3 months later. Results. There was no significant change in TOS and IMA levels of exercise group but TAS levels were significantly increased (p < 0.05). Also, postexercise systolic (p < 0.001) and diastolic (p < 0.05) blood pressures of the exercise group were significantly lower than the baseline values. In addition, there was no significant change in TAS and TOS levels of the non-exercise group; however, IMA levels were significantly increased (p < 0.01). Conclusion. We have shown, for the first time, that exercise prevents increase in IMA levels in type 2 DM which might have resulted from increased levels of TAS and reduces the risk of ischemia in these patients. These findings show that chronic exercise is beneficial in the prevention of oxidative stress in patients with type 2 DM as documented by decreased IMA levels.
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    Effect of Diet Oils on Lipid Levels of the Brain of Rats
    (Blackwell Publishing, 2006) Kurban, Sevil; Mehmetoğlu, İdris; Yılmaz, Gülsüm
    The effects of sunflower oil, olive oil, margarine, soybean oil and butter on cholesterol and triglyceride levels were investigated in the brain of rats. Rats were fed with a diet containing 15 % of the oils for a period of 8 weeks. The rats were then decapitated, brain samples were removed, homogenized and cholesterol and TG levels were measured. Brain cholesterol and Triglycerides levels of all animals receiving different oils were significantly higher according to the contol except TG level of animals receiving margarine. Brain cholesterol levels of the vegetable oils were statistically higher than those receiving saturated oil. Thus, cholesterol level of the rats fed with olive oil group was significantly higher than that of the other groups but those receiving sunflower oil group and Triglycerides level of the animals receiving olive oil was significantly higher than that of the other groups except animal supplemented with soybean oil. Thus, it is concluded that brain lipid levels of rats are differently effected by various oils and mechanism of which needs to be investigated.
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    Effect of preoperative atorvastatin therapy on paraoxonase activity and oxidative stress after coronary artery bypass grafting
    (SAGE PUBLICATIONS LTD, 2009) Kurban, Sevil; Mehmetoglu, Idris; Ege, Erdal
    The aim of this study was to examine the influence of preoperative atorvastatin therapy on oxidative stress in coronary artery bypass grafting (CABG) patients. Forty patients who underwent elective CABG were enrolled into the study. Of these patients, 20 received atorvastatin (Group I) for 15 days prior to surgery and 20 patients did not use any antihyperlipidemic agents preoperatively (Group II). Serum paraoxonase 1 (PON1) and arylesterase activities, and total antioxidant status (TAS) and total oxidant status (TOS) were measured before surgery and at 1, 6 and 24 hours after the operation. Paraoxonase 1 and arylesterase activities (p<0.001) and TAS levels (p<0.001 for 1(st) hour and p<0.05 for 6th hour) in Group II were significantly reduced at the 1(st) and 6(th) hours after the operation, whereas the activities of the enzymes (p<0.01) and TAS levels (p<0.05) were significantly reduced only at the 1(st) hour after the operation in Group I. The total oxidant status of both groups was significantly increased at the 1(st) hour after operation (p<0.05 for Group I and p<0.01 for Group II). In conclusion, 15 days of preoperative atorvastatin therapy does not significantly change either the serum PON1 activity or the oxidative stress after CABG.
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    Effects of Acetylsalicylic Acid on Serum Paraoxonase Activity, Ox-LDL, Coenzyme Q10 and Other Oxidative Stress Markers in Healthy Volunteers
    (PERGAMON-ELSEVIER SCIENCE LTD, 2010) Kurban, Sevil; Mehmetoğlu, İdris
    Objectives: The aim of the study was to examine the effects of acetylsalicylic acid (ASA) on oxidative stress in healthy volunteers. Design and Methods: 30 volunteers of which 17 received ASA as 100 mg/day (Group 1) and 13 received ASA as 150 mg/day (Group 11) for 2 months. Serum paraoxonase 1 (PON1), arylesterase, total antioxidant status (TAS), total oxidant status (TOS), oxidized LDL (Ox-LDL) and coenzyme Q(10) (CoQ(10)) levels were measured before and I and 2 months after treatment. Results: There was no significant differences between the measured parameters of the groups. However, TOS and Ox-LDL levels of group 11 were significantly reduced after 2 months of treatment (p<0.05). Conclusions: Significantly inhibition of LDL oxidation and significantly reduction in TOS levels of group II after 2 months of ASA treatment shows that ASA treatment may contribute to the prevention of atherosclerosis, a beneficial effect which is dose and time dependent.
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    The Effects of Free Radicals on Antioxidant Defence Systems and Organism in Hemodialysis Patients
    (CHEM SOC PAKISTAN, 2011) Yontem, Mustafa; Bilge, Murat; Kaleli, Suleyman; Kurban, Sevil; Celik, Gulperi
    Chronic Renal Failure (CRF) is accompanied by a variety of complications which may develop due to an increase in oxidant stress and/or a decrease in antioxidant activities. Hemodialysis (HD) is still the most prevalent method used for the end stage renal failure throughout the world. In this study, it was aimed to research thoroughly whether an increase in lipid peroxidation occurs in hemodialysis patients with advanced CRF and to evaluate antioxidant enzyme activities. Plasma MDA which is the indicator of lipid peroxidation and plasma SOD, CAT, GSH-Px levels as well as total antioxidant status (TAS) values which are the indicators of antioxidant defense systems have been determined in CRF patients who have undergone hemodialysis treatment and in the control group. Compared to those found in the control group, MDA and SOD levels in CRF patient group have statistically increased (p<0,001), while GSH-Px and CAT values have been found to decrease (p<0,001). TAS values have been determined to increase in the control group before the hemodialysis and to decrease after the hemodialysis, which is statistically insignificant. With regard to the correlation calculation we've made, a statistically positive correlation have been found between urea and creatinine both pre- and after hemodialysis, while no statistically significance have been recorded among other parameters.
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    Effects of phototherapy on serum paraoxonase activity and total antioxidant capacity in newborn jaundice
    (Nobelmedicus, 2014) Kurban, Sevil; Annagür, Ali; Altunhan, Hüseyin; Mehmetoğlu, İdris; Örs, Rahmi; Erdem, Said Sami; Yerlikaya, Fatma Hümeyra
    Objective: Phototherapy is an efficient and commonly used form of therapy for the treatment of neonatal hyperbilirubinemia. Paraoxonase 1 (PON1) is an antioxidative enzyme, which eliminates lipid peroxides. The aim of our study was to investigate the effect of phototherapy on serum PON1 activity and total antioxidant capacity (TAC) in hyperbilirubinemic full-term newborns.Material and Method: The study was performed on 40 full-term newborns between 3 to 15 days of age exposed to phototherapy.Serum PON1 activity and TAC levels of the babies were determinedbefore and after phototherapy by spectrophotometric assays.Results: We have found that PON1 activity was not significantly affected by phototherapy whereas TAC levels were decreased significantly after phototherapy (p<0.001).Conclusion: Our findings demonstrated that phototherapy has no direct effect on PON1 activity. Also, decreased TAC levels might have resulted from increased oxidative stress which may lead to consumption of antioxidant molecules. © 2014, Nobelmedicus. All rights reserved.
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    EFFECTS OF PHOTOTHERAPY ON SERUM PARAOXONASE ACTIVITY AND TOTAL ANTIOXIDANT CAPACITY IN NEWBORN JAUNDICE
    (NOBEL ILAC, 2014) Kurban, Sevil; Annagür, Ali; Altunhan, Hüseyin; Mehmetoğlu, İdris; Örs, Rahmi; Erdem, Said Sami; Yerlikaya, Fatma Hümeyra
    Objective: Phototherapy is an efficient and commonly used form of therapy for the treatment of neonatal hyperbilirubinemia. Paraoxonase 1 (PON1) is an anti oxidative enzyme, which eliminates lipid peroxides. The aim of our study was to investigate the effect of phototherapy on serum PON1 activity and total antioxidant capacity (TAC) in hyperbilirubinemic full-term newborns. Material and Method: The study was performed on 40 full-tenn newborns between 3 to 15 days of age exposed to phototherapy. SerumPON1 activity and TAC levels of the babies were determined before and after phototherapy by spectrophotometric assays. Results: We have found that PON1 activity was not significantly affected by phototherapy whereas TAC levels were decreased significantly after phototherapy (p<0.001). Conclusion: Our findings demonstrated that phototherapy has no direct effect on PON1 activity. Also, decreased TAC levels might have resulted from increased oxidative stress which may lead to consumption of antioxidant molecules.
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    Effects of two different doses of acetylsalicylic acid on serum nitric oxide, asymmetric dimethylarginine, and homocysteine levels in healthy volunteers
    (TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, 2012) Mehmetoglu, Idris; Kurban, Sevil
    Aim: To examine the effects of ASA on serum nitric oxide (NO), asymmetric dimethylarginine (ADMA), and homocysteine levels in healthy volunteers. Materials and methods: Totally, 26 apparently healthy volunteers were enrolled in the study. Of the participants, 13 (5F, 8M) received 100 mg of ASA daily and 13 (5F, 8M) received 150 mg of ASA daily for 2 months. Serum NO, ADMA, and homocysteine levels were measured before and 1 and 2 months after ASA treatment Serum NO, ADMA, and homocysteine levels were measured before and 1 and 2 months after ASA treatment. Results: ADMA levels of the group receiving 150 mg of ASA were significantly reduced after 2 months of treatment (P < 0.05). NO levels of both groups were slightly but not significantly increased and homocysteine levels of both groups were slightly reduced after ASA treatment compared to the baseline values. Conclusion: Our findings indicate that ASA treatment reduces ADMA levels dose and time dependently, a beneficial effect that may contribute to the prevention of cardiovascular diseases.
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    The evaluation of safety and analgesic efficacy of paracetamol and ibuprofen followed by impacted third molar surgery [Gömülü üçüncü molar diş ameliyatı öncesinde uygulanan parasetamol ve i?buprofenin a?rı kesici etkinli?i ve güvenli?i açısından de?erlendirilmesi]
    (TIP ARASTIRMALARI DERNEGI, 2010) Özkan, Birkan Taha; Durmuş, Ercan; Kalaycı, Abdullah; Kurban, Sevil; Akça, Cennet Neslihan
    Aim: The aim of this prospective, randomised, single-blind, single center, parallel group study was to compare the analgesic effects and safety of a single starting dose of soluble ibuprofen and 2 g of intravenous paracetamol for postoperative pain management in patients undergoing surgical removal of lower impacted third molar. Method: 30 patients who referred for surgical removal of bilateral impacted lower third molar teeth were included in the study. The patients were divided in to two groups. In the early preoperative period, the patients received a single starting dose of either soluble ibuprofen 400 mg dissolved in 100 ml of water or 15-min intravenous infusion of paracetamol 2 gram. Surgery in each patient was performed twice, 1 impacted tooth was being removed at a time and another one was being removed 2 weeks later. Trismus, safety variables and hepatotoxicity and analgesic efficacy were evaluated. Result: The analgesic efficacy over a 24-hour period was of statistically no significant difference between 2 groups but clinical data shows that the analgesic efficacy of paracetamol group was greater than ibuprofen group. As for the mean trismus values, there was no statistically significant difference between groups. The administered dosages of the analgesics did not lead to hepatocellular injury and biochemical abnormality. Conclusion: Consequently, both administered dosages of drugs can safely be used as a single starting doses. In order to obtain more better results with analgesic efficacy and safety in use, more trials are needed for administering higher doses of paracetamol and ibuprofen.
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    Fertil ve infertil şahıslarda seminal sıvı, serum lipid ve testosteron düzeyinin araştırılması
    (2005) Mehmetoğlu, İdris; Gürbüz, Fatma; Gürbüz, Recai; Gökçe, Recep; Kurban, Sevil
    Amaç: Fertil ve infertil şahıslarda seminal sıvı ile serum lipid ve testosteron seviyeleri arasındaki ilişkinin araştırılması. Çalışmanın yapıldığı yer: Selçuk Üniversitesi, Meram Tıp Fak., Biyokimya ABD, KONYA Materyal ve Metod: Çalışmamızda 21-32yaşları arasında (ortalama 25) 25 fertil şahıs ile 18-42 yaşları arasında (ortalama 29) 30 intertil şahısta serum trigliserid (TG), total kolesterol, yüksek dansiteli lipoprotein (HDL) kolesterol, düşük dansiteli lipoprotein (LDL) kolesterol, total ve serbest testosteron ile seminal sıvı analizi yapıldı. Bütün analizler rutin metodlarla gerçekleştirildi. Bulgular: Fertil şahıslarda total ve serbest testosteron düzeyleri infertil şahıslarınkinden hafif yüksek iken, total kolesterol düzeyleri anlamlı decede düşük, sperm sayısı ise anlamlı derecede yüksekti. İnfertil grupta serum total kolesterol düzeyi ile serum total ve serbest testosteron düzeyleri arasında önemli negatif korelasyon, tüm vakalarda ise serum total kolesterol düzeyi ile sperm sayısı arasında önemli negatif korelasyon bulundu. Sonuç: Bu bulgular, hiperkolesteroleminin koroner kalp hastalığı riski yanında azospermiye ve sonuçta infertiliteye de yol açabileceğini göstermektedir. Bulgularımız, çeşitli araştırmacıların bulguları ile uyum halinde olup literatür bulguları ışığında tartışıldı.
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    Homocysteine levels and total antioxidant capacity in children with acute rheumatic fever
    (PERGAMON-ELSEVIER SCIENCE LTD, 2008) Kurban, Sevil; Mehmetoglu, Idris; Oran, Bulent; Kiyici, Aysel
    Objective: The aim of the study was to investigate total antioxidant capacity (TAC) and homocysteine levels in children with acute rheumatic fever (ARF). Design and methods: Nineteen patients with ARE and twenty healthy children, age- and sex-matched were included in the study. Follow-up studies were made at the 7(th), 14(th), 21(st) and 28(th) day of diagnosis. Results: Children with ARF had significantly higher serum homocysteine levels and lower TAC than the same parameters of the controls at all measurements. Following the anti-inflammatory therapy, we found a progressive increase in TAC and a decrease in homocysteine levels of the patients. Conclusion: We concluded that increased serum homocysteine levels and decreased serum TAC of the patients with ARF can be considered as a sign of increased inflammation and oxidative stress in these patients which needs to be considered during therapy. Further studies are needed to understand the underlying mechanisms of these findings. (c) 2007 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.