Is There a Relationship Between Beginning Time and Efficiency of Octreotide in the Treatment of Experimental Acute Pancreatitis?

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dc.contributor.authorKafalı, M. Ertuğrul
dc.contributor.authorGül, Mehmet
dc.contributor.authorAlptekin, Hüsnü
dc.contributor.authorŞahin, Mustafa
dc.contributor.authorToy, Hatice
dc.contributor.authorAköz, Mehmet
dc.date.accessioned2020-03-26T18:30:46Z
dc.date.available2020-03-26T18:30:46Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPurpose: The efficacy of octreotide in the treatment of acute pancreatitis is controversial. Octreotide treatment for acute pancreatitis often shows poor correlation between results obtained in experimental studies and results of clinical trials. In a clinical setting, there is always a delay between the onset of the disease and initiation of the octreotide treatment. The aim of this study is to investigate the relationship between the beginning of treatment and alteration in effectiveness of octreotide. Methods: Acute pancreatitis was induced by pancreatic duct ligation in 50 rats. The rats were randomly divided into five groups. Octreotide was not used in group 1 (control group). Only single dose (4 mu g/kg) octreotide was administered subcutaneously to rats in group 2, having induced pancreatitis. Octreotide treatment was begun at different times (8th, 24th, 48th hour) in three other groups and continued treatment at a dosage of 4 mu g/kg t.i.d. The animals were sacrificed at the end of the 72nd hour and blood and tissue samples were collected. Results: Leukocyte count and plasma amylase values were less in groups 2 and 3. Hemorrhagic focuses were encountered less at pancreas tissues in group 3. Pancreatic necrosis and alveolar capillary basal membrane damage were lower in groups 3 and 4. No difference was found in fasting blood glucose, calcium and hematocrit. Conclusion: Octreotide had benefical effects in acute pancreatitis when octreotide treatment was begun in the first 24 hours.en_US
dc.identifier.citationKafali, M. E., Gul, M., Alptekin, H., Sahin, M., Toy, H., Akoz, M., (2012). Is There a Relationship Between Beginning Time and Efficiency of Octreotide in the Treatment of Experimental Acute Pancreatitis?. Journal of the Korean Surgical Society, 82(5), 296-301. Doi: 10.4174/jkss.2012.82.5.296
dc.identifier.doi10.4174/jkss.2012.82.5.296en_US
dc.identifier.endpage301en_US
dc.identifier.issn2233-7903en_US
dc.identifier.issue5en_US
dc.identifier.pmid22563536en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage296en_US
dc.identifier.urihttps://dx.doi.org/10.4174/jkss.2012.82.5.296
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28171
dc.identifier.volume82en_US
dc.identifier.wosWOS:000303374100004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKafali, M. Ertugrul
dc.institutionauthorAkoz, Mehmet
dc.institutionauthorToy, Hatice
dc.institutionauthorSahin, Mustafa
dc.institutionauthorAlptekin, Husnu
dc.institutionauthorGul, Mehmet
dc.language.isoenen_US
dc.publisherKorean Surgical Societyen_US
dc.relation.ispartofJournal of the Korean Surgical Societyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectPancreatitisen_US
dc.subjectOctreotideen_US
dc.subjectAmylaseen_US
dc.titleIs There a Relationship Between Beginning Time and Efficiency of Octreotide in the Treatment of Experimental Acute Pancreatitis?en_US
dc.typeArticleen_US

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