Effect of Antioxidant Therapy on Collagen Synthesis in Corrosive Esophageal Burns

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dc.contributor.authorGünel, Engin
dc.contributor.authorÇağlayan, Fatma
dc.contributor.authorÇağlayan, Osman
dc.contributor.authorCanbilen, Aydan
dc.contributor.authorTosun, Murat
dc.date.accessioned2020-03-26T16:38:53Z
dc.date.available2020-03-26T16:38:53Z
dc.date.issued2002
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractTo investigate the efficacy of antioxidant therapy on collagen synthesis in corrosive esophageal burns, 110 Sprague-Dawley rats were divided into five groups of 22 animals each. A standard esophageal caustic burn was produced by 1 ml of 10% sodium hydroxide solution for the rats in groups B to E, group A was instilled only with 0.9% saline after preparation of the distal esophageal segment. Group A animals (controls) were uninjured and untreated. Group B had untreated esophageal burns. Esophageal burns were treated in group C with vitamin E (10 mg/kg IM), in group D with vitamin C (10 mg/kg IP), and in group E with methylprednisolone (30 mg/kg IM) on each of 5 days. Eight rats from each group were killed 4 days after initiation of the study and the abdominal esophagus was studied for tissue malondialdehyde (MDA; mumol/g protein) levels. The other rats were killed 28 days after initiation of the study and determination of hydroxyproline (HP) (mug/g tissue) levels in esophageal tissue was performed for 8 rats in each group. Histopathologic evaluation was also performed in the other 6 rats from each group. MDA levels in esophageal tissue were significantly lower in groups C (9.24 +/- 2.62, P < 0.01) and group E (6.26 +/- 2.22, P < 0.001) than in group B (12.35 +/- 1.80). HP levels were significantly lower in groups A (0.75 +/- 0.2 1, P < 0.001), C (1.11 +/- 0.15, P < 0.01), and E (0.96 +/- 0.15, P < 0.001) than in group B (1.40 +/- 0.20). Histopathologically, collagen deposition in the submucosa and tunica muscularis was lower in groups C and E than in group B (P < 0.05, and 0.01, respectively). Our results demonstrate that treatment with antioxidant drugs such as vitamin E and methylprednisolone decreased tissue HP levels, and thus inhibited new collagen synthesis and stricture formation in rats with alkali-induced caustic esophageal burns.en_US
dc.identifier.citationGünel, E., Çağlayan, F., Çağlayan, O., Canbilen, A., Tosun, M., (2002). Effect of Antioxidant Therapy on Collagen Synthesis in Corrosive Esophageal Burns. Pediatric Surgery International, (18), 24-27. Doi: 10.1007/s003830200005
dc.identifier.doi10.1007/s003830200005en_US
dc.identifier.endpage27en_US
dc.identifier.issn0179-0358en_US
dc.identifier.pmid11793058en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage24en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s003830200005
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17926
dc.identifier.volume18en_US
dc.identifier.wosWOS:000173856500006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGünel, Engin
dc.institutionauthorÇağlayan, Fatma
dc.institutionauthorÇağlayan, Osman
dc.institutionauthorCanbilen, Aydan
dc.institutionauthorTosun, Murat
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Surgery Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectesophageal burn corrosiveen_US
dc.subjecttherapyen_US
dc.subjectantioxidanten_US
dc.titleEffect of Antioxidant Therapy on Collagen Synthesis in Corrosive Esophageal Burnsen_US
dc.typeArticleen_US

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