The Effects of Splenic Artery Ligation in an Experimental Model of Secondary Hypersplenism

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dc.contributor.authorŞahin, Mustafa
dc.contributor.authorTekin, Şakir
dc.contributor.authorAksoy, Fatih
dc.contributor.authorVatansev, Hüsamettin
dc.contributor.authorŞeker, Muzaffer
dc.contributor.authorAvunduk, Mustafa Cihat
dc.contributor.authorKartal, Adil
dc.date.accessioned2020-03-26T16:36:21Z
dc.date.available2020-03-26T16:36:21Z
dc.date.issued2000
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: To induce hypersplenism in rats by splenic vein ligation and to investigate the effects of splenic artery ligation in this model. Background: Selective arterial embolisation and splenic artery ligation (SAI,) are used in the treatment of secondary hypersplenism in some medical centres but these methods are not common. Materials and Methods: Thirty male Saprague-Dawley rats were allocated to three groups (n=10). The first group underwent laparotomy, the second and third groups underwent laparotomy and splenic vein ligation. At the end of the third week, laparotomy was performed in the first and second groups and splenic artery ligation in the third group. Erythrocyte, leukocyte and platelet counts were performed weekly. At the end of the sixth week, the animals were sacrificed and the spleens were taken for histopathologic examination. Results: In the second and third groups, after splenic vein ligation, the erythrocyte and platelet counts mere significantly reduced at the end of the second week (p<0.01), In the second group, which underwent splenic vein ligation only, the levels remained low throughout the experiment. In the third group, after splenic artery ligation, there were rises in both erythrocyte and platelet counts; the levels were similar to the levels in the control group at three weeks after splenic artery ligation (p>0.05), No significant changes were observed in the leukocyte counts throughout the experiment (p>0.05), Conclusions: Splenic vein ligation successfully induces experimental secondary hypersplenism, This state can be ameliorated by splenic artery ligation.en_US
dc.identifier.citationSahin, M., Tekin, S., Aksoy, F., Vatansev, H., Seker, M., Avunduk, M. C., Kartal, A., (2000). The Effects of Splenic Artery Ligation in an Experimental Model of Secondary Hypersplenism. Journal of the Royal College of Surgeons of Edinburgh, 45(3), 148-152.
dc.identifier.endpage152en_US
dc.identifier.issn0035-8835en_US
dc.identifier.issue3en_US
dc.identifier.pmid10881479en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage148en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17265
dc.identifier.volume45en_US
dc.identifier.wosWOS:000088011100003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorSahin, M
dc.institutionauthorTekin, S
dc.institutionauthorAksoy, F
dc.institutionauthorVatansev, H
dc.institutionauthorSeker, M
dc.institutionauthorAvunduk, M. C
dc.institutionauthorKartal, A
dc.language.isoenen_US
dc.publisherRoyal College Surgeons Edinburghen_US
dc.relation.ispartofJournal of the Royal College of Surgeons of Edinburghen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectsecondary hypersplenismen_US
dc.subjectsplenic vein ligationen_US
dc.subjectsplenic artery ligationen_US
dc.titleThe Effects of Splenic Artery Ligation in an Experimental Model of Secondary Hypersplenismen_US
dc.typeArticleen_US

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