Enteral Glutamine Supplementation and Dexamethasone Attenuate the Local Intestinal Damage in Rats With Experimental Necrotizing Enterocolitis

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dc.contributor.authorDilsiz, Alaeddin
dc.contributor.authorÇiftçi, İlhan
dc.contributor.authorAktan, Tahsin Murad
dc.contributor.authorGürbilek, Mehmet
dc.contributor.authorKaragözoğlu, Emrah
dc.date.accessioned2020-03-26T16:45:43Z
dc.date.available2020-03-26T16:45:43Z
dc.date.issued2003
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe pathogenesis of necrotizing enterocolitis (NEC) presumptively is due to an inappropriate intestinal epithelial immunologic response of immature gut to luminal stimuli. Glutamine is essential for intestinal crypt cell proliferation and enhances the cellular response to growth factors. We aimed to test the hypothesis that the supplementation of enteral feedings with glutamine may stimulate an immature intestine and decrease the intestinal inflammatory change in NEC. Immediately after birth, the neonatal rats were weighed and randomized into one of four treatment groups. Group 1 consisted of rats whom were breast-fed. Group 2 (NEC group) consisted of neonates whom were fed with a special rodent formula. Rats in groups 3 and 4 were fed in a similar fashion to those in group 2, and glutamine 0.3 mg/kg per day and dexamethasone 0.5 mg/kg per day were added to their formula, respectively. The neonatal rats were weighed and killed on day 4: the last 4 cm of terminal ileum was harvested for morphological studies and detection of nitrite and nitrate levels in tissue. The animals in the NEC group showed various degrees of inflammatory changes similar to clinical NEC. The inflammatory changes of the intestine appeared to be attenuated in both glutamine- and steroid-treated animals compared to those in the NEC group. Only steroid treatment decreased the tissue levels of these nitrogen oxides that were increased in rats in the NEC group. We herein provide evidence that maturational agents such as glutamine and dexametasone can attenuate the local intestinal inflammatory damage in experimental NEC. These findings support the hypothesis that the gut immaturity in premature infants represents a risk factor for NEC.en_US
dc.identifier.citationDilsiz, A., Çiftçi, İ., Aktan, T. M., Gürbilek, M., Karagözoğlu, E., (2003). Enteral Glutamine Supplementation and Dexamethasone Attenuate the Local Intestinal Damage in Rats With Experimental Necrotizing Enterocolitis. Pediatric Surgery International, 19(8), 578-582. Doi: 10.1007/s00383-003-0980-y
dc.identifier.doi10.1007/s00383-003-0980-yen_US
dc.identifier.endpage582en_US
dc.identifier.issn0179-0358en_US
dc.identifier.issue8en_US
dc.identifier.pmid14556027en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage578en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00383-003-0980-y
dc.identifier.urihttps://hdl.handle.net/20.500.12395/18464
dc.identifier.volume19en_US
dc.identifier.wosWOS:000186494700003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDilsiz, Alaeddin
dc.institutionauthorÇiftçi, İlhan
dc.institutionauthorAktan, T. Murad
dc.institutionauthorGürbilek, Mehmet
dc.institutionauthorKaragözoğlu, Emrah
dc.language.isoenen_US
dc.publisherSpringer-Verlagen_US
dc.relation.ispartofPediatric Surgery Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectNecrotizing enterocolitisen_US
dc.subjectGlutamineen_US
dc.subjectDexamethasoneen_US
dc.subjectGut maturationen_US
dc.titleEnteral Glutamine Supplementation and Dexamethasone Attenuate the Local Intestinal Damage in Rats With Experimental Necrotizing Enterocolitisen_US
dc.typeArticleen_US

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